Fentanyl Citrate Injection USP (Preservative-Free) – Synthetic Opioid Analgesic for Clinical Use

Fentanyl Citrate Injection USP is a potent synthetic opioid analgesic intended for use in medically supervised settings such as hospitals and surgical centers. It is primarily used for the management of severe pain and as an adjunct to anesthesia during surgical procedures, diagnostic interventions, or intensive care situations.

This injectable formulation is typically administered intravenously or intramuscularly by qualified healthcare professionals under strict monitoring due to its high potency and risk of respiratory depression. It acts rapidly on the central nervous system by binding to opioid receptors, producing strong analgesia and sedation.

Clinical Indications & Performance of fentanyl citrate injection USP

According to institutional profiles on DailyMed and Pfizer Medical, the drug is primary utilized for:

Short-Duration Analgesia: Providing rapid pain relief during anesthetic periods (premedication, induction, and maintenance).

Anesthetic Supplement: Serving as a narcotic supplement in general or regional anesthesia.

High-Risk Procedures: Acting as a primary anesthetic agent alongside oxygen in select major surgeries (e.g., open-heart or complex neurosurgery).

Potency Reference: A dose of 100 mcg (0.1 mg) is roughly equivalent in analgesic action to 10 mg of morphine.

Available Dosage Forms

The solution is distributed globally through approved drug registers by manufacturers such as Hikma Pharmaceuticals and Fresenius Kabi, packaged as single-dose glass ampules, vials, or prefilled syringes ranging from 0.5 mL to 50 mL.

Disclaimer: Fentanyl Citrate Injection, USP is a Schedule II controlled substance. It carries boxed warnings on Drugs.com for severe risks of addiction, abuse, misuse, and fatal respiratory depression. It must only be administered by trained healthcare professionals equipped with oxygen and opioid reversal agents like naloxone.