Oxycodone/Acetaminophen Tablets 2.5 mg/325 mg (Rx Only)
Oxycodone/Acetaminophen 2.5 mg/325 mg tablets are a prescription medication that combines oxycodone, an opioid analgesic, with acetaminophen, a non-opioid pain reliever. This combination is used for the management of pain when treatment with an opioid-containing medication is considered appropriate by a healthcare provider.
This prescription medication is an oral, immediate-release combination tablet containing a low-dose opioid agonist alongside a non-opiate analgesic and antipyretic. Each precisely formulated tablet delivers a dual-action mechanism to target the central nervous system and peripheral pain signaling paths.
Active Ingredients & Strengths
Oxycodone Hydrochloride, USP (2.5 mg): A semisynthetic pure opioid agonist that works primarily by binding to mu-opioid receptors in the brain and spinal cord to alter the perception of pain. (Equivalent to 2.2409 mg of pure oxycodone free base).
Acetaminophen, USP (325 mg): A trusted non-opiate, non-salicylate compound that provides synergistic pain relief and fever reduction.
Each tablet contains:
- Oxycodone Hydrochloride 2.5 mg
- Acetaminophen 325 mg
Indications & Clinical Use
Primary Indication: Prescribed for the acute management of moderate to moderately severe pain when alternative non-opioid treatments are inadequate or cannot be tolerated.
Target Audience: Ideal for adults requiring specialized pain management under direct clinical supervision.
Key Features & Practical Benefits
Synergistic Formulation: Combining a low-dose opioid with acetaminophen maximizes analgesic efficacy while keeping the opioid intake per tablet to a minimum baseline.
Fast-Acting Relief: Designed as an immediate-release oral dose to respond promptly to pain flare-ups.
Physical Characteristics: Typically manufactured as a small, distinctively marked oval tablet (such as the pink, debossed brand-name variant or generic equivalents) for easy identification and patient compliance.
Important Safety Information
Oxycodone/Acetaminophen carries risks of addiction, abuse, misuse, respiratory depression, overdose, and death. Take only as prescribed by a licensed healthcare professional. Do not exceed the prescribed dosage, and avoid combining with alcohol or other medications that may cause drowsiness unless directed by your healthcare provider. Keep out of reach of children.







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